Description

5-Bromo-3,4-Difluoro-2-Methoxyphenylboronic Acid is a high-purity, multi-functional boronic acid derivative designed for advanced organic synthesis. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used to construct complex heterocyclic scaffolds found in modern herbicides, fungicides, and insecticides.
• Ligand & Catalyst Development: Serves as a starting material for creating specialized ligands and organometallic catalysts.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as OLED and OFET components.
• Chemical Biology Probes: Utilized to build molecules for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds under cGMP conditions.

Basic Information

Product Name	5-Bromo-3,4-Difluoro-2-Methoxyphenylboronic Acid
CAS No.	1256346-43-6
Molecular Formula	C7H6BBrF2O3
Molecular Weight	266.84 g/mol
Synonyms	(5-Bromo-3,4-difluoro-2-methoxyphenyl)boronic acid; 2-Methoxy-5-bromo-3,4-difluorophenylboronic acid; 5-Bromo-3,4-difluoro-2-methoxybenzeneboronic acid; Boronic acid, B-(5-bromo-3,4-difluoro-2-methoxyphenyl)-; CAS 1256346-43-6
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-3,4-Difluoro-2-Methoxyphenylboronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) including HPLC purity, NMR confirmation, and residual solvent analysis is supplied with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.