Description

Besifovir is a potent antiviral compound, specifically a nucleotide analog, with significant therapeutic potential. Its primary value lies in its targeted mechanism of action against viral polymerases, making it a critical active pharmaceutical ingredient (API) for antiviral drug development. This compound is essential for pharmaceutical manufacturers and research institutions focused on developing treatments for viral infections, particularly within antiviral and anti-hepatitis research programs.

Application

• Active Pharmaceutical Ingredient (API): Primary use in the formulation of antiviral medications.
• Antiviral Research: Key reference standard and investigational compound in virology and pharmacology studies.
• Hepatitis B Treatment Development: Core component in research and development of next-generation hepatitis B virus (HBV) therapeutics.
• Biochemical Assays: Used as a standard or inhibitor in enzymatic studies targeting viral replication mechanisms.
• Preclinical and Clinical Trials: Serves as the bulk drug substance for toxicity, pharmacokinetic, and efficacy studies.
• Pharmaceutical Intermediates: May be used in the synthesis of more complex antiviral prodrugs or derivatives.

Basic Information

Product Name	Besifovir
CAS No.	1254032-66-0
Molecular Formula	C15H19N6O5PS
Molecular Weight	426.39 g/mol
Synonyms	Besifovir; LB80380; LB-80380; (2S)-2-[(S)-[[(2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl]methoxy](phenoxy)phosphorylamino]propanoic acid isopropyl ester; 1-(4-Fluoro-5-hydroxy-4-methyl-3-((S)-((S)-1-isopropoxy-1-oxopropan-2-yl)(phenoxy)phosphorylamino)methoxy)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

Our Besifovir is manufactured under strict quality management systems to ensure it meets the high-purity standards required for pharmaceutical research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant ICH guidelines and can support development projects requiring material suitable for preclinical and clinical studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤1.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.