Description

2,3-Difluoro-n-Methylbenzamide is a high-purity fluorinated aromatic amide building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of fluorine atoms is crucial for modulating biological activity and metabolic stability. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate a difluorinated benzamide motif into their target molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, receptor modulators, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance lipophilicity and environmental stability.
• Material Science Research: Serves as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials requiring fluorinated aromatic units.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological systems and enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	2,3-Difluoro-n-Methylbenzamide
CAS No.	1250397-72-8
Molecular Formula	C8H7F2NO
Molecular Weight	171.15 g/mol
Synonyms	N-Methyl-2,3-difluorobenzamide; 2,3-Difluoro-N-methylbenzamide; Benzamide, N-methyl-2,3-difluoro-; 2,3-Difluorobenzoic acid methylamide
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-n-Methylbenzamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.