Description

Tenofovir Fumarate CAS NO 1246812-23-6 is the fumarate salt form of tenofovir, a potent nucleotide reverse transcriptase inhibitor (NRTI). This high-purity active pharmaceutical ingredient (API) is critical for the formulation of reliable and effective antiviral medications. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of antiviral therapies.

Application

• Pharmaceutical API: Primary active ingredient in the manufacture of antiviral tablets and capsules.
• HIV Treatment: Essential component in combination antiretroviral therapy (cART) regimens for HIV-1 infection.
• Hepatitis B Treatment: Used in formulations for chronic hepatitis B virus (HBV) infection management.
• Pre-Exposure Prophylaxis (PrEP): Key ingredient in medications used for HIV prevention in high-risk populations.
• Pharmaceutical Research: Reference standard and building block for novel antiviral drug discovery and development.
• Generic Drug Manufacturing: Sourcing for the production of bioequivalent generic antiviral medications.
• Formulation Development: Used in R&D for optimizing drug delivery systems, stability, and bioavailability.

Basic Information

Product Name	Tenofovir Fumarate
CAS No.	1246812-23-6
Molecular Formula	C23H34N5O14P
Molecular Weight	635.51 g/mol
Synonyms	Tenofovir Fumarate Salt; (R)-9-(2-Phosphonomethoxypropyl)adenine Fumarate; PMPA Fumarate; GS 1278; TDF Fumarate; Bis(POC)PMPA Fumarate; Viread® API (Fumarate Form); Tenofovir Disoproxil Fumarate Impurity/Intermediate
EINECS	Contact for details

Quality Control

Our Tenofovir Fumarate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. Certificates of Analysis (COA) are provided, confirming compliance with relevant pharmacopeial standards (e.g., USP, EP) and in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Specific Optical Rotation	-15.0° to -18.0°

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.