Description

3-Fluoro-2-(Hydroxymethyl)Phenylboronic Acid is a versatile and highly functionalized boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its value lies in the unique combination of a reactive boronic acid group for Suzuki-Miyaura cross-coupling and a hydroxymethyl substituent for further derivatization, enabling the construction of complex fluorinated molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise, high-purity intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in creating novel fluorinated pesticides, herbicides, and fungicides, where the fluorine atom enhances biological activity, stability, and metabolic resistance.
• Ligand & Catalyst Development: Serves as a precursor for sophisticated ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.
• Material Science Research: Employed in the synthesis of fluorinated polymers, liquid crystals, and organic electronic materials for OLEDs and semiconductors.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and bio-conjugates for imaging and diagnostic applications.
• Cross-Coupling Reactions: Primarily functions as an arylboronic acid partner in Suzuki-Miyaura cross-coupling reactions to form biaryl and heterobiaryl structures.

Basic Information

Item	Detail
Product Name	3-Fluoro-2-(Hydroxymethyl)Phenylboronic Acid
CAS No.	1246633-55-5
Molecular Formula	C7H8BFO3
Molecular Weight	169.95 g/mol
Synonyms	(3-Fluoro-2-(hydroxymethyl)phenyl)boronic acid; 2-(Hydroxymethyl)-3-fluorobenzeneboronic acid; 3-Fluoro-2-(hydroxymethyl)benzeneboronic acid; B-(3-Fluoro-2-(hydroxymethyl)phenyl)boronic acid; 3-Fluoro-2-hydroxymethylphenylboronic Acid; 1246633-55-5; AI3-52362
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-2-(Hydroxymethyl)Phenylboronic Acid is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for research and commercial synthesis. We provide full traceability and a detailed Certificate of Analysis (COA) with each shipment, confirming identity, purity, and impurity profiles via techniques such as NMR, HPLC, and mass spectrometry. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.