Description

2-Fluoro-6-(Hydroxymethyl)Phenylboronic Acid is a specialized bifunctional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a boronic acid group and a hydroxymethyl substituent on a fluorinated aromatic ring, makes it a versatile reagent for constructing complex molecular architectures. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for applications in Suzuki-Miyaura cross-coupling reactions and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially in oncology and CNS therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: Essential reagent for forming carbon-carbon bonds to create biaryl structures, a common motif in many functional molecules.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Ligand and Catalyst Development: Serves as a precursor for creating sophisticated ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the development of organic electronic materials, such as those for OLEDs and organic semiconductors.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and sensors for studying biological processes and diagnostics.

Basic Information

Item	Details
Product Name	2-Fluoro-6-(Hydroxymethyl)Phenylboronic Acid
CAS No.	1246633-54-4
Molecular Formula	C7H8BFO3
Molecular Weight	169.95 g/mol
Synonyms	(2-Fluoro-6-(hydroxymethyl)phenyl)boronic acid; 2-Fluoro-6-(hydroxymethyl)benzeneboronic acid; B-(2-Fluoro-6-(hydroxymethyl)phenyl)boronic acid; 2-Fluoro-6-hydroxymethylphenylboronic acid; 2-Fluoro-6-methylolphenylboronic acid; 1246633-54-4; (2-Fluoro-6-methylolphenyl)boronic acid
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-6-(Hydroxymethyl)Phenylboronic Acid is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the high standards required for research and commercial synthesis. Our quality protocols are designed to guarantee batch-to-batch consistency, purity, and reliability. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.