Description

3-Fluoro-2-Formylbenzeneboronic Acid Pinacol Ester is a high-value, multifunctional boronic ester building block essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in pharmaceutical and advanced materials research. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing biaryl or heterobiaryl motifs.
• Agrochemical Research: Used in the discovery and development of novel herbicides, fungicides, and insecticides requiring specific fluorinated aromatic structures.
• Material Science: Serves as a precursor for creating functionalized polymers, liquid crystals, and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The primary application is as a coupling partner in palladium-catalyzed Suzuki-Miyaura reactions to introduce the 3-fluoro-2-formylphenyl moiety.
• Chemical Synthesis: Utilized in further derivatization, where the formyl group can undergo condensation, reduction, or other transformations to access a diverse library of compounds.
• Ligand & Catalyst Development: Acts as a building block for synthesizing novel bidentate or tridentate ligands used in catalysis.

Basic Information

Product Name	3-Fluoro-2-Formylbenzeneboronic Acid Pinacol Ester
CAS No.	1246633-35-1
Molecular Formula	C₁₄H₁₈BFO₃
Molecular Weight	264.10 g/mol
Synonyms	(3-Fluoro-2-formylphenyl)boronic acid pinacol ester; 2-Formyl-3-fluorophenylboronic acid pinacol ester; 3-Fluoro-2-formylbenzeneboronic acid, pinacol cyclic ester; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-fluorobenzaldehyde; 6-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde; 3-Fluoro-2-formylphenylboronic acid pinacol ester; PINACOL (3-FLUORO-2-FORMYLPHENYL)BORONATE
EINECS	Contact for details

Quality Control

Our 3-Fluoro-2-Formylbenzeneboronic Acid Pinacol Ester is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed using advanced techniques including NMR, HPLC, and GC to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.