Description

Cholest-5-Ene-3,22(S)-Diol-D7 is a high-purity, deuterium-labeled sterol derivative, specifically designed for use as an analytical standard and a stable isotope-labeled intermediate. This compound is critical for ensuring accuracy and reliability in quantitative mass spectrometry and metabolic pathway studies. It is primarily utilized by pharmaceutical research organizations, contract research laboratories, and academic institutions engaged in advanced lipidomics, biomarker discovery, and drug metabolism and pharmacokinetics (DMPK) research.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard for the analysis of cholesterol and its hydroxylated metabolites in biological matrices.
• Metabolic Pathway Tracing: Employed in stable isotope labeling studies to investigate cholesterol biosynthesis, transport, and catabolism.
• Biomarker Research: Facilitates the precise measurement of oxysterols and other sterol derivatives in disease state studies.
• Pharmaceutical Development: Serves as a key labeled intermediate in the synthesis of deuterated drug candidates for improved metabolic stability.
• Quality Control & Method Validation: Essential for developing and validating robust analytical methods in regulatory environments.
• Academic Research: Supports fundamental research in biochemistry and cell biology related to lipid signaling and membrane structure.

Basic Information

Product Name	Cholest-5-Ene-3,22(S)-Diol-D7
CAS No.	1246302-91-9
Molecular Formula	C₂₇H₄₁D₇O₂
Molecular Weight	~411.7 g/mol
Synonyms	22(S)-Hydroxycholesterol-d7; (22S)-22-Hydroxycholesterol-d7; 22S-Hydroxycholesterol-d7; Cholest-5-ene-3β,22S-diol-d7; 3β,22S-Dihydroxycholest-5-ene-d7; Deuterated 22(S)-HC; 22(S)-HC-d7; Stable Isotope Labeled 22(S)-Hydroxycholesterol
EINECS	Contact for details

Quality Control

Every batch of Cholest-5-Ene-3,22(S)-Diol-D7 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, verified by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, isotopic enrichment, and solvent content. Our quality commitment ensures the reliability required for sensitive applications in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.