Description

2-Cyclopropylmethoxy-4,5-Difluorophenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative, serving as a critical building block in modern organic synthesis. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, where it is used to develop novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates containing difluorophenyl and cyclopropyl motifs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science: Building block for creating organic electronic materials, such as ligands for OLEDs or components for organic semiconductors.
• Chemical Biology & Medicinal Chemistry: Employed in the discovery and optimization of drug candidates through library synthesis and structure-activity relationship (SAR) studies.
• Catalyst & Ligand Development: Serves as a precursor for synthesizing novel palladium catalysts or specialized ligands used in cross-coupling reactions.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Item	Details
Product Name	2-Cyclopropylmethoxy-4,5-Difluorophenylboronic Acid Pinacol Ester
CAS No.	1245816-08-3
Molecular Formula	C₁₆H₂₁BF₂O₃
Molecular Weight	310.15 g/mol
Synonyms	2-(Cyclopropylmethoxy)-4,5-difluorophenylboronic acid pinacol ester; 4,5-Difluoro-2-(cyclopropylmethoxy)phenylboronic acid pinacol ester; [2-(Cyclopropylmethoxy)-4,5-difluorophenyl]boronic acid pinacol ester; 2-Cyclopropylmethoxy-4,5-difluorobenzeneboronic acid pinacol ester; B-[2-(Cyclopropylmethoxy)-4,5-difluorophenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; CAS 1245816-08-3
EINECS	Contact for details

Quality Control

Every batch of 2-Cyclopropylmethoxy-4,5-Difluorophenylboronic Acid Pinacol Ester is manufactured and tested under a strict quality management system. We ensure compliance with rigorous internal specifications, which are designed to meet the exacting standards of research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.