Description

(1R,4S)-1,2,3,4-Tetrahydro-1,4-Epoxynaphthalene-1-Carboxylic Acid CAS NO 1244954-14-0 is a high-purity, chiral epoxide-containing carboxylic acid derivative, serving as a critical advanced pharmaceutical intermediate (API) and a versatile chiral building block. Its value lies in its rigid, fused bicyclic structure which provides a defined three-dimensional framework essential for inducing stereoselectivity in complex organic syntheses. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of novel therapeutic agents, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Chiral Ligand & Catalyst Synthesis: Building block for creating novel asymmetric catalysts and auxiliaries used in enantioselective transformations.
• Agrochemical Research: Intermediate in the development of new, stereospecific pesticides and herbicides where biological activity is chirality-dependent.
• Material Science Monomer: Potential monomer for synthesizing specialized polymers with unique thermal or optical properties derived from its naphthalene and epoxide functionalities.
• Academic & Discovery Chemistry: Used in research laboratories for methodology development and exploring new reaction pathways involving strained epoxides and carboxylic acids.
• Fine Chemical Synthesis: Intermediate for producing complex, high-value fragrance compounds, flavors, and other specialty chemicals requiring precise stereochemistry.

Basic Information

Product Name	(1R,4S)-1,2,3,4-Tetrahydro-1,4-Epoxynaphthalene-1-Carboxylic Acid
CAS No.	1244954-14-0
Molecular Formula	C11H10O3
Molecular Weight	190.20 g/mol
Synonyms	(1R,4S)-1,4-Epoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid; (1R,4S)-1-Carboxy-1,4-epoxy-1,2,3,4-tetrahydronaphthalene; (1R,4S)-1,2,3,4-Tetrahydro-1,4-epoxynaphthalene-1-carboxylic acid; (1R,4S)-THEC; 1,4-Epoxytetralin-1-carboxylic acid (stereospecific); (1R,4S)-1,2,3,4-Tetrahydro-1,4-epoxy-1-naphthoic acid; (1R,4S)-1,4-Epoxytetralin-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our (1R,4S)-1,2,3,4-Tetrahydro-1,4-Epoxynaphthalene-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure high chemical and optical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.