Description

Tenofovir Disoproxil Isopropoxycarbonyl is a key pharmaceutical intermediate and prodrug form of Tenofovir, an important nucleotide reverse transcriptase inhibitor. This compound is critical for ensuring the efficacy and bioavailability of final active pharmaceutical ingredients (APIs) used in antiviral therapies. It is primarily required by manufacturers in the pharmaceutical industry engaged in the synthesis of advanced antiviral medications.

Application

• Primary intermediate in the synthesis of Tenofovir Alafenamide (TAF) and related prodrugs.
• Critical raw material for the production of antiviral Active Pharmaceutical Ingredients (APIs) targeting HIV and Hepatitis B.
• Used in pharmaceutical research and development for novel nucleotide analog formulations.
• Essential component in the manufacturing process of combination antiretroviral therapies.
• Serves as a reference standard in analytical laboratories for quality control and method validation.
• Employed in process chemistry for scaling up production under current Good Manufacturing Practice (cGMP) conditions.

Basic Information

Product Name	Tenofovir Disoproxil Isopropoxycarbonyl
CAS No.	1244022-54-5
Molecular Formula	C21H34N5O9P
Molecular Weight	531.50 g/mol
Synonyms	Tenofovir Isopropyl Carbonate; GS-7340 Isopropoxycarbonyl Intermediate; (R)-PMPA Isopropoxycarbonyl Prodrug; 9-[(R)-2-[[Bis[[(isopropoxycarbonyl)oxy]methoxy]phosphinyl]methoxy]propyl]adenine; Isopropoxycarbonyloxymethyl Tenofovir Disoproxil; TAF Intermediate; Tenofovir Disoproxil Isopropyl Ester Carbonate
EINECS	Contact for details

Quality Control

Our Tenofovir Disoproxil Isopropoxycarbonyl is manufactured under strict quality systems suitable for pharmaceutical intermediates. The product undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and conformity to stringent specifications. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing all critical quality attributes. Production can be aligned with cGMP guidelines to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.