Description

Estrone-[2,3,4-13C3] is a stable isotope-labeled analog of the natural estrogen hormone estrone, specifically enriched with carbon-13 at the 2, 3, and 4 positions of the steroid ring. This compound is an essential internal standard for the precise and accurate quantification of endogenous estrone levels in complex biological matrices using mass spectrometry-based analytical techniques. It is primarily utilized by research institutions, clinical diagnostic laboratories, and pharmaceutical companies engaged in endocrinology research, steroid metabolism studies, and the development of high-sensitivity bioanalytical assays.

Application

• Quantitative Mass Spectrometry: Serves as a critical internal standard for Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Mass Spectrometry (GC-MS) methods to ensure accuracy and correct for matrix effects.
• Clinical Diagnostics: Enables precise measurement of estrone in serum, plasma, and urine for hormonal disorder assessment, fertility studies, and monitoring hormone replacement therapies.
• Endocrinology & Metabolism Research: Used in tracer studies to investigate the biosynthesis, metabolic pathways, and pharmacokinetics of estrogenic hormones in vivo and in vitro.
• Pharmaceutical Development: Supports bioanalytical method development and validation for drug candidates that interact with the endocrine system, ensuring regulatory compliance for pharmacokinetic studies.
• Food & Environmental Analysis: Applied in methods to detect and quantify trace levels of estrogenic compounds or endocrine-disrupting chemicals in food products and environmental samples.
• Forensic Toxicology: Aids in the confirmatory analysis of steroid hormones in anti-doping control and forensic investigations.

Basic Information

Product Name	Estrone-[2,3,4-13C3]
CAS No.	1241684-29-6
Molecular Formula	C18H2213C3O2
Molecular Weight	273.35 g/mol (for 13C3 labeled form)
Synonyms	1,3,5(10)-Estratrien-3-ol-17-one-[2,3,4-13C3]; 3-Hydroxyestra-1,3,5(10)-trien-17-one-[2,3,4-13C3]; [13C3]-Estrone; 13C3 Labeled Estrone; Estrone-13C3; Estra-1,3,5(10)-trien-3-ol-17-one-13C3; Folliculin-[2,3,4-13C3]; Ketohydroxyestrin-[2,3,4-13C3]
EINECS	Contact for details

Quality Control

Our Estrone-[2,3,4-13C3] is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm chemical identity, isotopic enrichment, and purity. Certificates of Analysis (COA) are provided, detailing batch-specific data on assay, isotopic purity, and solvent residues, supporting compliance with GLP and ISO 17025 standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store under an inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99 atom % 13C
Isotopic Enrichment	≥ 99% at positions 2,3,4
Chemical Purity	≥ 95%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.