Description

Leukotriene D4-D5 is a high-purity biochemical reference standard, specifically a mixture of the cysteinyl leukotrienes LTD4 and LTE5. This compound is critical for research and development within the life sciences, serving as a key mediator in the study of inflammatory and allergic response pathways. It is an essential tool for pharmaceutical researchers, clinical diagnostic developers, and academic institutions focused on respiratory diseases, immunology, and drug discovery.

Application

• Pharmacological Research: Used as a reference standard in studies investigating the role of cysteinyl leukotrienes in asthma, allergic rhinitis, and other inflammatory conditions.
• Drug Discovery & Development: Serves as a critical target or calibrant in high-throughput screening (HTS) assays for identifying and characterizing leukotriene receptor antagonists.
• Clinical Diagnostics: Employed as a calibration standard in immunoassays (e.g., ELISA) to quantify leukotriene levels in biological samples for clinical research.
• Biochemical Pathway Analysis: Essential for in vitro and ex vivo studies to elucidate the arachidonic acid cascade and eicosanoid signaling mechanisms.
• Academic & Institutional Research: Provides a validated standard for university and government lab studies in immunology, pulmonology, and cell biology.
• Quality Control: Used by manufacturers of diagnostic kits and pharmaceutical ingredients to ensure assay accuracy and product consistency.

Basic Information

Product Name	Leukotriene D4-D5
CAS No.	1240398-17-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	LTD4/LTE5 Mixture; Cysteinyl Leukotriene D4-E5; 5(S)-Hydroxy-6(R)-S-cysteinylglycyl-7,9-trans-11,14-cis-eicosatetraenoic Acid / 5(S)-Hydroxy-6(R)-S-cysteinyl-7,9-trans-11,14-cis-eicosatetraenoic Acid Mixture; Leukotriene D4 and E5; LTD4/LTE5 Reference Standard; (5S,6R)-6-[(2S)-2-Amino-2-carboxyethyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid / (5S,6R)-6-[(2S)-2-Amino-2-carboxyethyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid glycine conjugate mixture
EINECS	Contact for details

Quality Control

Our Leukotriene D4-D5 is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC and MS, to ensure identity, purity, and stability. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be kept under desiccated conditions. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area Percent)
LTD4 : LTE5 Ratio	Specified on COA
Water Content (KF)	≤ 5.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.