Description

3-Bromo-5-Trifluoromethyl-Benzoic Acid tert-Butyl Ester CAS NO 1237535-81-7 is a high-purity, advanced pharmaceutical intermediate characterized by its bromine and trifluoromethyl functional groups on a benzoic acid ester backbone. This compound is a critical building block for medicinal chemistry, enabling the synthesis of complex molecules with enhanced metabolic stability and bioavailability. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly in therapeutic areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group can improve biological activity.
• Material Science: Serves as a monomer or functionalizing agent in the synthesis of specialty polymers and liquid crystals.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce complex aromatic systems into target molecules.
• Chemical Biology Probes: Utilized in the creation of labeled compounds and molecular probes for biochemical and diagnostic research.

Basic Information

Product Name	3-Bromo-5-Trifluoromethyl-Benzoic Acid tert-Butyl Ester
CAS No.	1237535-81-7
Molecular Formula	C12H12BrF3O2
Molecular Weight	325.13 g/mol
Synonyms	tert-Butyl 3-bromo-5-(trifluoromethyl)benzoate; Benzoic acid, 3-bromo-5-(trifluoromethyl)-, 1,1-dimethylethyl ester; 3-Bromo-5-(trifluoromethyl)benzoic acid tert-butyl ester; 3-Bromo-α,α,α-trifluoro-m-toluic acid tert-butyl ester; 1,1-Dimethylethyl 3-bromo-5-(trifluoromethyl)benzoate
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Trifluoromethyl-Benzoic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.