Description

Hydroxy Ivabradine is a key pharmaceutical intermediate and a derivative of the selective heart rate-reducing agent Ivabradine. This compound is critical for the research and development of novel cardiovascular therapeutics targeting specific ion channels in the sinoatrial node. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the synthesis of advanced cardiac drugs, process optimization, and analytical method development.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of Ivabradine and its related analogs for cardiovascular treatments.
• Research & Development: Used in preclinical and clinical research to study heart rate modulation and develop new therapeutic entities.
• Process Chemistry: Employed in the scale-up and optimization of manufacturing processes for active pharmaceutical ingredients (APIs).
• Reference Standard: Acts as a high-purity standard for quality control and analytical method validation in pharmaceutical laboratories.
• Chemical Synthesis: Utilized in organic synthesis for creating novel molecular structures with potential pharmacological activity.

Basic Information

Product Name	Hydroxy Ivabradine
CAS No.	1235547-07-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	7,8-Dimethoxy-3-{7-[(3aS,4S,7aR)-octahydro-2H-isoindol-2-yl]heptyl}-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one derivative; Ivabradine Hydroxy Derivative; Ivabradine Related Compound; (3aR,7aS)-2-[7-[(7,8-Dimethoxy-2-oxo-1,3,4,5-tetrahydro-2H-3-benzazepin-3-yl)heptyl]octahydro-1H-isoindole
EINECS	Contact for details

Quality Control

Our Hydroxy Ivabradine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing all specifications are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature. The material should be kept under an inert atmosphere if long-term stability is required.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.