Description

Deldeprevir is a highly selective, non-covalent hepatitis C virus (HCV) NS5A inhibitor developed for antiviral research and pharmaceutical development. It serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the formulation of next-generation direct-acting antivirals. Researchers and API manufacturers rely on Deldeprevir CAS NO 1229626-28-1 for preclinical validation, analytical method development, and process optimization in regulated drug manufacturing environments.

Application

• Pharmaceutical R&D: Lead compound optimization and structure-activity relationship (SAR) studies for HCV NS5A inhibitors
• Reference Standard: Quantitative HPLC and LC-MS calibration for assay validation and stability testing
• API Synthesis Intermediate: Key building block in multi-step synthesis of clinical-stage NS5A-targeting therapeutics
• Regulatory Submissions: Included in impurity profiling, forced degradation studies, and ICH Q5/Q7 compliance documentation
• Bioanalytical Support: Used in developing and qualifying bioanalytical methods for pharmacokinetic (PK) and toxicokinetic (TK) studies
• Quality Control Laboratories: Primary standard for identity confirmation and purity assessment in GMP-compliant testing labs

Basic Information

Product Name	Deldeprevir
CAS No.	1229626-28-1
Molecular Formula	C28H28F3N5O3
Molecular Weight	555.55 g/mol
Synonyms	Deldeprevir; BMS-790052 analog; 5-[[2-(4-Chlorophenyl)-5-methyl-1,3-thiazol-4-yl]methyl]-N-[(1R,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-4H-1,2,4-triazol-3-amine; NS5A inhibitor 28; BMS-790052 derivative; Deldeprevir (USAN); (R)-5-((2-(4-chlorophenyl)-5-methylthiazol-4-yl)methyl)-N-(2-hydroxy-2,3-dihydro-1H-inden-1-yl)-4H-1,2,4-triazol-3-amine; Deldeprevir free base
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches are tested per ICH Q2(R2) guidelines for identification, assay, residual solvents, heavy metals, and related substances. Testing includes HPLC purity ≥99.5%, chiral purity ≥99.0% ee, and residual solvent compliance per ICH Q3C. Available grades meet USP, EP, and JP pharmaceutical reference standard specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8°C under inert atmosphere (nitrogen or argon) to prevent oxidation. Keep away from moisture and strong oxidizing agents. Maintain in a cool, dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	99.0–101.0%
Related Substances (HPLC)	≤0.5% total impurities
Single Impurity	≤0.10%
Residual Solvents (GC)	Meets ICH Q3C limits
Heavy Metals	≤10 ppm
Water (Karl Fischer)	≤0.5%
Optical Rotation	[α]D20 = –15.0° to –18.0° (c = 1, MeOH)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.