Description

(R)-4-tert-Butoxy-4-Oxo-2-Phenylbutanoic Acid CAS NO 1229381-08-1 is a high-purity chiral intermediate characterized by its tert-butoxy and phenyl substituents. This compound is of significant value in the synthesis of complex pharmaceutical molecules, particularly those requiring a specific (R)-enantiomer configuration for optimal biological activity. It is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the development of active pharmaceutical ingredients (APIs) and other advanced organic compounds.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel APIs, especially for central nervous system (CNS) and cardiovascular drugs.
• Asymmetric Synthesis: Used as a precursor in catalytic asymmetric reactions to construct complex molecular architectures with high enantiomeric purity.
• Peptidomimetic Research: Serves as a constrained amino acid analog in the development of peptide-based therapeutics and enzyme inhibitors.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands and organocatalysts for use in stereoselective transformations.
• Reference Standard: Utilized as a high-purity analytical standard for method development and quality control in pharmaceutical R&D and manufacturing.

Basic Information

Product Name	(R)-4-tert-Butoxy-4-Oxo-2-Phenylbutanoic Acid
CAS No.	1229381-08-1
Molecular Formula	C14H18O4
Molecular Weight	250.29 g/mol
Synonyms	(R)-4-(tert-Butoxy)-4-oxo-2-phenylbutanoic acid; (R)-2-Phenylsuccinic acid 4-tert-butyl ester; (R)-4-tert-Butoxy-4-oxo-2-phenylbutyric acid; (R)-O-tert-Butyl hydrogen 2-phenylsuccinate; (2R)-4-(tert-Butoxy)-2-phenyl-4-oxobutanoic acid; (R)-2-Phenyl-4-(tert-butoxy)-4-oxobutanoic acid; (R)-H-Phe-OtBu
EINECS	Contact for details

Quality Control

Our (R)-4-tert-Butoxy-4-Oxo-2-Phenylbutanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider using a desiccator or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.