Description

S-3,3'-Bis(3,5-Bis(Trifluoromethyl)Phenyl)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Bi-2,2'-Naphthol is a high-value, chiral binaphthol derivative distinguished by its unique perfluorinated aromatic substituents. This compound is a critical ligand precursor and organocatalyst in advanced asymmetric synthesis, enabling the production of enantiomerically pure pharmaceuticals and fine chemicals. It is essential for R&D and manufacturing chemists in the pharmaceutical, agrochemical, and specialty materials sectors who require precise stereochemical control.

Application

• Asymmetric Catalysis: As a privileged chiral ligand for transition metal complexes (e.g., with Ru, Rh, Pd) in enantioselective hydrogenation, C-C bond formation, and other key transformations.
• Organocatalysis: Direct use as a chiral Brønsted acid or bifunctional catalyst for promoting stereoselective reactions.
• Pharmaceutical Intermediates: Synthesis of chiral active pharmaceutical ingredients (APIs) where high enantiomeric excess is mandatory.
• Agrochemical Synthesis: Production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Advanced Material Research: Building block for chiral polymers, liquid crystals, and molecular recognition systems.
• Academic & Industrial R&D: A versatile tool for method development and exploring new asymmetric synthetic pathways.

Basic Information

Product Name	S-3,3'-Bis(3,5-Bis(Trifluoromethyl)Phenyl)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Bi-2,2'-Naphthol
CAS No.	1228600-99-4
Molecular Formula	C40H26F12O2
Molecular Weight	742.62 g/mol
Synonyms	(S)-H8-BINOL-3,3'-bis(3,5-bis(trifluoromethyl)phenyl); (S)-Octahydro-3,3'-bis[3,5-bis(trifluoromethyl)phenyl]-1,1'-bi-2-naphthol; S-3,3'-Di(3,5-di(trifluoromethyl)phenyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl-2,2'-diol; (S)-3,3'-Bis(3,5-bis(trifluoromethyl)phenyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl-2,2'-diol; S-3,3'-Bis(3,5-di(trifluoromethyl)phenyl)-H8-BINOL; S-3,3'-Bis(perfluorotolyl)-H8-BINOL
EINECS	Contact for details

Quality Control

Our production of this chiral compound adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, 1H/19F NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess (ee), and identity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.