Description

((4-Trifluoromethyl)Phenyl)Di-tert-Butylphosphine,85% CAS NO 1228182-34-0 is a specialized organophosphorus ligand primarily used in transition metal catalysis. This compound matters for its role in facilitating highly efficient and selective cross-coupling reactions, which are fundamental to modern pharmaceutical and advanced material synthesis. It is a critical reagent for R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require robust catalytic systems.

Application

• Pharmaceutical Intermediate Synthesis: As a key ligand in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Negishi) for constructing complex biaryl and heteroaryl structures.
• Agrochemical Research & Development: Used in the catalytic synthesis of novel active ingredients requiring the introduction of trifluoromethylphenyl groups.
• Material Science & OLED Development: Employed in the catalytic formation of conjugated polymers and small molecules for electronic and optoelectronic applications.
• Academic & Industrial Catalysis Research: Serves as a sterically demanding, electron-donating ligand for developing new catalytic methodologies and optimizing reaction conditions.
• Fine Chemical Production: Facilitates the scalable, catalytic manufacture of high-value, fluorinated specialty chemicals.

Basic Information

Product Name	((4-Trifluoromethyl)Phenyl)Di-tert-Butylphosphine, 85%
CAS No.	1228182-34-0
Molecular Formula	C₁₅H₂₂F₃P
Molecular Weight	290.30 g/mol
Synonyms	Di-tert-butyl(4-(trifluoromethyl)phenyl)phosphine; (4-(Trifluoromethyl)phenyl)bis(1,1-dimethylethyl)phosphine; Di-tert-butyl(4-trifluoromethylphenyl)phosphine; (4-CF3-Ph)P(t-Bu)2; Ligand for cross-coupling; t-Bu-P(4-CF3-Ph)-t-Bu; Phosphine ligand CAS 1228182-34-0
EINECS	Contact for details

Quality Control

Our production of ((4-Trifluoromethyl)Phenyl)Di-tert-Butylphosphine adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for catalytic applications. Each lot is analyzed to confirm identity, purity, and absence of critical impurities that could deactivate catalysts. A comprehensive Certificate of Analysis (COA) detailing assay (typically 85% min), NMR characterization, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, well-ventilated place. This material is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain efficacy.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Assay (NMR / GC)	85% min
Solubility	Soluble in common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.