Description

Racemic-trans-1,2-Bis[Di(3,5-Dimethylphenyl)Phosphinomethyl]Cyclobutane is a specialized chiral diphosphine ligand of significant interest in advanced catalytic chemistry. Its value lies in its unique sterically demanding and electron-rich structure, which is crucial for inducing high enantioselectivity and activity in asymmetric synthesis. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require precise control over stereochemistry in metal-catalyzed reactions such as hydrogenations and cross-couplings.

Application

• Asymmetric Hydrogenation Catalyst Ligand: A key component for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Cross-Coupling Reactions: Used as a ligand in palladium or nickel-catalyzed reactions like Suzuki-Miyaura and Buchwald-Hartwig aminations for constructing complex molecules.
• Homogeneous Catalysis Research: Serves as a valuable tool for developing new catalytic systems in academic and industrial R&D laboratories.
• Fine Chemical Synthesis: Enables the production of high-value, optically active compounds for flavors, fragrances, and advanced materials.
• Agrochemical Intermediate Production: Facilitates the creation of chiral active ingredients with improved efficacy and environmental profiles.

Basic Information

Item	Detail
Product Name	Racemic-trans-1,2-Bis[Di(3,5-Dimethylphenyl)Phosphinomethyl]Cyclobutane
CAS No.	1226906-44-0
Molecular Formula	C44H52P2
Molecular Weight	642.82 g/mol
Synonyms	trans-1,2-Bis[(di-3,5-xylylphosphino)methyl]cyclobutane (racemic); DTBM-Cyclobutane; Di(3,5-dimethylphenyl)phosphine-based cyclobutane ligand; 1,2-Bis[bis(3,5-dimethylphenyl)phosphinomethyl]cyclobutane (rac, trans); DTBM-CB; Josiphos-type ligand analog; Chiral diphosphine ligand 1226906-44-0
EINECS	Contact for details

Quality Control

Every batch of our Racemic-trans-1,2-Bis[Di(3,5-Dimethylphenyl)Phosphinomethyl]Cyclobutane is produced and analyzed under strict quality management protocols to ensure consistency and reliability for sensitive catalytic applications. We employ advanced analytical techniques including NMR, HPLC, and elemental analysis to verify identity, purity, and the absence of critical metallic impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation, this material should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Palladium (Pd) Content	≤ 50 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.