Description

(R)-4-tert-Butyl-2-[(Sp)-2-(Diphenylphosphino)Ferrocenyl]-2-Oxazoline CAS NO 1226898-27-6 is a highly specialized, chiral ferrocenyl-oxazoline ligand, a cornerstone in modern asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity in a wide range of transition-metal-catalyzed reactions, enabling the synthesis of optically pure compounds. This product is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, critical for producing chiral intermediates in active pharmaceutical ingredients (APIs).
• Asymmetric C-C Bond Formation: Employed in reactions such as allylic alkylation, hydroformylation, and cross-coupling to construct complex molecular architectures with high stereofidelity.
• Pharmaceutical Intermediate Synthesis: Facilitates the production of single-enantiomer drug candidates and chiral building blocks for medicinal chemistry.
• Agrochemical Research: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Material Science & Specialty Polymers: Catalyzes the synthesis of chiral monomers and polymers with unique optical or electronic properties.
• Academic & Industrial R&D: A vital tool for methodology development and exploring new catalytic transformations in academic and corporate research laboratories.

Basic Information

Product Name	(R)-4-tert-Butyl-2-[(Sp)-2-(Diphenylphosphino)Ferrocenyl]-2-Oxazoline
CAS No.	1226898-27-6
Molecular Formula	C31H32FeNOP
Molecular Weight	521.41 g/mol
Synonyms	(R)-4-tert-Butyl-2-[(Sp)-2-(Diphenylphosphino)ferrocenyl]-4,5-dihydrooxazole; (R)-4-tert-Butyl-2-[(Sp)-2-(Diphenylphosphino)ferrocenyl]-2-oxazoline; (R)-t-Bu-PHOX; (R)-tert-ButylPHOX; (R)-4-tert-Butyl-2-(2-(diphenylphosphino)ferrocenyl)-4,5-dihydrooxazole; (R)-4-tert-Butyl-2-(2-diphenylphosphinoferrocenyl)-2-oxazoline; (R)-2-[2-(Diphenylphosphino)ferrocenyl]-4-tert-butyl-2-oxazoline
EINECS	Contact for details

Quality Control

Our high-value chiral ligands are produced and handled under strict quality protocols to ensure batch-to-batch consistency and optimal catalytic performance. Each lot undergoes comprehensive analysis, including HPLC for chiral purity and assay, NMR for structural confirmation, and elemental analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at a controlled room temperature (15-25°C) in a cool, dry place. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light may degrade performance.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.