Description

2-[(4-Trifluoromethyl)Phenyl]Isonicotinic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique trifluoromethylphenyl-pyridinecarboxylic acid structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate its distinct fluorinated aromatic moiety into new molecular entities.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of the trifluoromethyl group on bioavailability, metabolic stability, and binding affinity.
• Agrochemical Development: Serves as a precursor in the research and production of advanced pesticides and herbicides, where the fluorine atoms can enhance activity and environmental persistence.
• Ligand Synthesis: Employed in the creation of specialized ligands for catalysis and material science applications.
• Chemical Biology Probes: Utilized to develop molecular probes for studying biological pathways and target validation.

Basic Information

Product Name	2-[(4-Trifluoromethyl)Phenyl]Isonicotinic Acid
CAS No.	1225900-99-1
Molecular Formula	C13H8F3NO2
Molecular Weight	267.21 g/mol
Synonyms	2-[4-(Trifluoromethyl)phenyl]pyridine-4-carboxylic acid; 4-Pyridinecarboxylic acid, 2-[4-(trifluoromethyl)phenyl]-; 2-(4-Trifluoromethylphenyl)isonicotinic acid; Isonicotinic acid, 2-(4-trifluoromethylphenyl)-; 2-(4-(Trifluoromethyl)phenyl)isonicotinic Acid
EINECS	Contact for details

Quality Control

Our 2-[(4-Trifluoromethyl)Phenyl]Isonicotinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.