Description

D,L-2-Amino-3-(Hydroxy-15N-Amino)Propionic Acid is a stable isotope-labeled analog of serine, where the nitrogen atom in the amino group is enriched with the 15N isotope. This compound is a critical building block for the synthesis of isotopically labeled peptides, proteins, and other biomolecules, enabling advanced research in metabolic pathway tracing, protein structure determination, and quantitative proteomics. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and specialized CROs (Contract Research Organizations) engaged in mass spectrometry-based studies and nuclear magnetic resonance (NMR) spectroscopy.

Application

• Isotopic Tracer in Metabolic Studies: Used to track and quantify the metabolic flux of serine and related amino acids in cellular and in vivo systems.
• Internal Standard for Mass Spectrometry: Serves as a high-purity, chemically identical internal standard for the accurate quantification of serine and its derivatives in LC-MS/MS and GC-MS analyses.
• Biomolecular NMR Spectroscopy: Essential for the site-specific isotopic labeling of proteins, facilitating the study of protein dynamics, folding, and ligand interactions.
• Synthesis of Labeled Pharmaceuticals: A key precursor in the synthesis of 15N-labeled drug candidates for pharmacokinetic and pharmacodynamic studies.
• Proteomics and Biomarker Discovery: Enables stable isotope labeling by amino acids in cell culture (SILAC) and other quantitative proteomic techniques.
• Enzyme Mechanism Studies: Used to investigate enzyme kinetics and mechanisms involving nitrogen transfer or amino acid metabolism.

Basic Information

Product Name	D,L-2-Amino-3-(Hydroxy-15N-Amino)Propionic Acid
CAS No.	1219426-14-8
Molecular Formula	C₃H₈¹⁵N₂O₃
Molecular Weight	122.09 g/mol (for 15N labeled form)
Synonyms	DL-Serine-15N; (RS)-Serine-15N; (±)-Serine-15N; 2-Amino-3-hydroxypropanoic acid-15N; Serine (15N labeled); 15N-Serine; 15N Labeled Serine; DL-15N-Serine
EINECS	Contact for details

Quality Control

Every batch of D,L-2-Amino-3-(Hydroxy-15N-Amino)Propionic Acid is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high standards required for research and development. Specifications typically include isotopic enrichment (atom % 15N), chemical purity, and chiral purity. Certificates of Analysis (COA) detailing lot-specific results from NMR, HPLC, and mass spectrometry are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (argon or nitrogen) after opening to maintain stability and prevent degradation. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % 15N)	≥ 98%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.