Description

D,L-Alanosine-15N2 is a stable isotope-labeled analog of the glutamine antagonist alanosine, specifically labeled with two nitrogen-15 atoms. This labeled compound is essential for advanced metabolic and pharmacokinetic studies, providing researchers with a precise tracer for mass spectrometry and NMR analysis. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions engaged in cancer research, metabolic pathway analysis, and drug discovery.

Application

• Isotopic Tracer in Metabolic Studies: Used in mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy to track glutamine metabolism and amino acid utilization in cell cultures and animal models.
• Cancer Research & Drug Development: Serves as a critical tool for investigating the mechanism of action of alanosine and related glutamine analogs in targeting cancer cell proliferation.
• Biochemical Assay Standard: Employed as an internal standard for the quantitative analysis of alanosine in complex biological matrices, ensuring assay accuracy and reproducibility.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Research: Facilitates precise measurement of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical studies.
• Enzyme Inhibition Studies: Used to study the inhibition of enzymes like glutaminase and other targets within glutamine-dependent metabolic pathways.

Basic Information

Product Name	D,L-Alanosine-15N2
CAS No.	1219187-51-5
Molecular Formula	C3H715N2O4
Molecular Weight	150.08 g/mol (for 15N2 labeled form)
Synonyms	L-Alanosine-15N2; DL-Alanosine-15N2; (2S)-2-Amino-3-(hydroxynitrosoamino)propanoic acid-15N2; NSC 153353-15N2; SDX-102-15N2; 3-(N-Hydroxy-N-nitrosoamino)-L-alanine-15N2; Antibiotic 250A-15N2
EINECS	Contact for details

Quality Control

Our D,L-Alanosine-15N2 is manufactured under strict quality systems to ensure high isotopic and chemical purity for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and identity confirmation. We adhere to relevant standards for stable isotope-labeled compounds to ensure reliable and reproducible performance in sensitive analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (15N)	≥ 98 atom % 15N
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.