Description

2-(Di-1-Adamantylphosphino) Dimethylaminobenzene,97% Me-Dalphos CAS NO 1219080-77-9 is a highly specialized, sterically demanding monodentate phosphine ligand, crucial for enabling challenging cross-coupling and other transition metal-catalyzed reactions. Its value lies in providing exceptional stability and selectivity to catalytic systems, particularly for substrates prone to side reactions like β-hydride elimination. This advanced ligand is essential for researchers and process chemists in pharmaceutical development, agrochemical synthesis, and fine chemical manufacturing who require high-performance catalysts.

Application

• Palladium-Catalyzed Cross-Coupling Reactions: A premier ligand for Buchwald-Hartwig amination, Suzuki-Miyaura, and Negishi couplings, especially with sterically hindered or electronically deactivated substrates.
• Pharmaceutical Intermediate Synthesis: Enables the efficient and selective construction of C-N and C-C bonds in complex drug molecule scaffolds.
• Agrochemical Active Ingredient Production: Used in catalytic steps for synthesizing advanced herbicides, fungicides, and insecticides.
• Material Science & OLED Precursor Synthesis: Facilitates the coupling of aromatic systems required for electronic materials and organic light-emitting diodes.
• Academic & Industrial R&D: A valuable tool for developing new catalytic methodologies and exploring novel reaction pathways in laboratory settings.
• Fine Chemical & Specialty Chemical Manufacturing: Applied in the production of high-value, complex organic molecules where selectivity and yield are paramount.

Basic Information

Item	Details
Product Name	2-(Di-1-Adamantylphosphino) Dimethylaminobenzene,97% Me-Dalphos
CAS No.	1219080-77-9
Molecular Formula	C28H38NP
Molecular Weight	419.58 g/mol
Synonyms	Me-Dalphos; 2-(Diadamantylphosphino)-N,N-dimethylaniline; 2-(Bis(adamantan-1-yl)phosphanyl)-N,N-dimethylaniline; 2-(Di-1-adamantylphosphino)-N,N-dimethylaniline; Dimethyl[2-(tricyclo[3.3.1.13,7]dec-1-ylphosphanyl)phenyl]amine; Buchwald Ligand Me-Dalphos; (2-(Dimethylamino)phenyl)di-1-adamantylphosphine
EINECS	Contact for details

Quality Control

Our Me-Dalphos ligand is manufactured under strict quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot undergoes comprehensive analysis, including NMR (1H, 31P) and HPLC to verify identity, purity, and the absence of critical impurities like phosphine oxides. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry place at 2-8°C to maximize shelf life and prevent oxidation. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
31P NMR Purity	≥ 97.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.