Description

2-Formyl-5-(trifluoromethoxy)phenylboronic acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a formyl group and a trifluoromethoxy substituent, makes it an exceptionally versatile reagent for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in cross-coupling reactions like the Suzuki-Miyaura reaction.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group can enhance biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of novel organic electronic materials, such as those for OLEDs or sensors.
• Ligand and Catalyst Development: Employed in the creation of sophisticated ligands for transition metal catalysis, enabling more efficient and selective synthetic transformations.
• Chemical Biology & Proteomics: Utilized in the design and synthesis of molecular probes and activity-based protein profiling (ABPP) agents due to its reactive boronic acid moiety.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis organizations (CSOs) and CROs working on client-specific, complex molecule projects.

Basic Information

Product Name	2-Formyl-5-(Trifluoromethoxy)Phenylboronic Acid
CAS No.	1218790-89-6
Molecular Formula	C8H6BF3O4
Molecular Weight	233.94 g/mol
Synonyms	[5-(Trifluoromethoxy)-2-formylphenyl]boronic acid; 2-Formyl-5-(trifluoromethoxy)benzeneboronic acid; 5-(Trifluoromethoxy)-2-formylbenzeneboronic acid; Boronic acid, B-[5-(trifluoromethoxy)-2-formylphenyl]-; 2-Carboxy-5-(trifluoromethoxy)phenylboronic acid (tautomeric form); CAS 1218790-89-6
EINECS	Contact for details

Quality Control

Every batch of 2-Formyl-5-(trifluoromethoxy)phenylboronic acid is manufactured and tested under a strict quality management system. We guarantee high purity and batch-to-batch consistency through rigorous analytical protocols, including HPLC, NMR, and LC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to ensure compliance with your research and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.