Description

2-Cyano-4-(Trifluoromethyl)Phenylboronic Acid is a high-value organoboron building block essential for modern synthetic chemistry, particularly in cross-coupling reactions. Its molecular structure, featuring both a cyano and a trifluoromethyl group, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for drug discovery and the synthesis of advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), especially those requiring fluorinated or nitrile-containing aromatic systems.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge-transport layers.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Useful for labeling and modifying biomolecules in proteomics and medicinal chemistry research.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	2-Cyano-4-(Trifluoromethyl)Phenylboronic Acid
CAS No.	1218790-84-1
Molecular Formula	C8H5BF3NO2
Molecular Weight	214.94 g/mol
Synonyms	[2-Cyano-4-(trifluoromethyl)phenyl]boronic acid; (2-Cyano-4-(trifluoromethyl)phenyl)boronic acid; 2-Cyan-4-(trifluormethyl)phenylboronsäure (German); Boronic acid, B-[2-cyano-4-(trifluoromethyl)phenyl]-; 2-Cyano-4-trifluoromethylbenzeneboronic acid; 4-Trifluoromethyl-2-cyanophenylboronic acid; 2-CN-4-CF3-PhB(OH)2
EINECS	Contact for details

Quality Control

Our 2-Cyano-4-(Trifluoromethyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with relevant regulatory frameworks for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.