Description

5-Amino-2,4-Difluorophenylboronic Acid, Hcl is a high-purity, functionalized boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, where the boronic acid group enables Suzuki-Miyaura cross-coupling reactions, and the aromatic amine provides a handle for further derivatization. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, especially those containing difluorophenyl motifs for improved metabolic stability and bioavailability.
• Suzuki-Miyaura Cross-Coupling: Used as a versatile boronic acid coupling partner to construct biaryl and heterobiaryl structures central to many bioactive compounds.
• Agrochemical Synthesis: Employed in the research and development of novel herbicides, fungicides, and insecticides with specific targeting properties.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of advanced polymers, OLED materials, and sensors.
• Chemical Biology & Proteomics: Utilized in the development of chemical probes and affinity ligands for studying biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	5-Amino-2,4-Difluorophenylboronic Acid, Hcl
CAS No.	1218790-76-1
Molecular Formula	C6H7BClF2NO2
Molecular Weight	209.39 g/mol
Synonyms	5-Amino-2,4-difluorobenzeneboronic acid hydrochloride; (5-Amino-2,4-difluorophenyl)boronic acid hydrochloride; 2,4-Difluoro-5-aminophenylboronic acid HCl; Boronic acid, B-(5-amino-2,4-difluorophenyl)-, hydrochloride; 1218790-76-1; 5-Amino-2,4-DFPBA HCl
EINECS	Contact for details

Quality Control

Our 5-Amino-2,4-Difluorophenylboronic Acid, Hcl is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and scale-up applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can support development under cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.