Description

5-Fluoro-2-(n-Methylsulfamoyl)Phenylboronic Acid is a high-value organoboron building block, specifically a functionalized phenylboronic acid derivative. Its core value lies in enabling precise Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern pharmaceutical and agrochemical synthesis. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-purity intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the fluorine and sulfonamide motifs for bioactivity.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical boronic acid partner for forming carbon-carbon bonds, enabling the construction of biaryl and heterobiaryl structures prevalent in drug discovery.
• Material Science Research: Investigated for the development of organic electronic materials, sensors, and metal-organic frameworks (MOFs) due to its functional handle for polymerization or coordination.
• Chemical Biology & Probe Development: Utilized in creating molecular probes and tools for studying biological processes and enzyme inhibition.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales, from gram to kilogram.

Basic Information

Product Name	5-Fluoro-2-(n-Methylsulfamoyl)Phenylboronic Acid
CAS No.	1218790-75-0
Molecular Formula	C7H9BFNO4S
Molecular Weight	233.03 g/mol
Synonyms	(5-Fluoro-2-((N-methylsulfamoyl)phenyl)boronic acid; 2-Borono-5-fluoro-N-methylbenzenesulfonamide; 5-Fluoro-2-(N-methylsulfamoyl)benzeneboronic acid; [5-Fluoro-2-(methylsulfamoyl)phenyl]boronic acid; B-[5-Fluoro-2-[(methylamino)sulfonyl]phenyl]boronic acid; 5-Fluoro-2-(methylsulfamoyl)phenylboronic acid; 1218790-75-0
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-(n-Methylsulfamoyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting cGMP (current Good Manufacturing Practice) compliance for use in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the primary container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.