Description

4-Amino-1-[(2R,5S)-2-(Hydroxymethyl)-1,3-Oxathiolan-5-Yl]Pyrimidin-2-One is a high-purity nucleoside analog intermediate of significant importance in advanced pharmaceutical synthesis. This compound matters for its role as a critical building block in the development of antiviral and anticancer therapeutics, where stereochemical purity is paramount. It is primarily needed by research institutions, pharmaceutical development labs, and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of nucleoside-based antiviral drugs.
• Antiviral Drug Development: Serves as a precursor in the synthesis of experimental therapeutics targeting viral polymerases.
• Oncology Research: Used in the development of chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate nucleotide metabolism pathways.
• Process Chemistry: Utilized for scaling up and optimizing synthetic routes for complex nucleoside analogs under GMP conditions.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory filings in pharmaceutical manufacturing.

Basic Information

Product Name	4-Amino-1-[(2R,5S)-2-(Hydroxymethyl)-1,3-Oxathiolan-5-Yl]Pyrimidin-2-One
CAS No.	1217746-03-6
Molecular Formula	C8H11N3O3S
Molecular Weight	229.26 g/mol
Synonyms	Lamivudine Impurity; (-)-2'-Deoxy-3'-thiacytidine Related Compound; β-L-2',3'-Dideoxy-3'-thiacytidine; 4-Amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone; L-(-)-2',3'-Dideoxy-3'-thiacytidine; 3TC Intermediate; Oxathiolane Cytosine Derivative; Nucleoside Oxathiolane Analog
EINECS	Contact for details

Quality Control

Our 4-Amino-1-[(2R,5S)-2-(Hydroxymethyl)-1,3-Oxathiolan-5-Yl]Pyrimidin-2-One is manufactured under strict quality systems to ensure batch-to-batch consistency and high stereochemical purity, suitable for advanced pharmaceutical applications. All products undergo rigorous analytical testing, including chiral HPLC, NMR, and mass spectrometry, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (2R,5S isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.