Description

3,3',5'-Triiodothyronine-(Diiodophenyl-13C6) Hydrochloride is a high-purity, stable isotope-labeled analog of the thyroid hormone triiodothyronine (T3). This compound is critical for use as an internal standard in mass spectrometry-based analytical methods, ensuring unparalleled accuracy and reliability in quantitative bioanalysis. It is primarily utilized by pharmaceutical R&D laboratories, clinical research organizations, and diagnostic manufacturers for method development, validation, and high-throughput screening in pharmacokinetic and metabolic studies.

Application

• Internal Standard for LC-MS/MS: Essential for the precise quantification of endogenous or exogenous triiodothyronine (T3) and related metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Pharmaceutical R&D: Supports drug metabolism and pharmacokinetics (DMPK) studies for thyroid hormone analogs or modulators, enabling accurate tracking of compound absorption, distribution, metabolism, and excretion.
• Clinical Research & Diagnostics: Used in the development and validation of robust clinical assays for measuring thyroid function, aiding in the diagnosis and monitoring of thyroid disorders such as hyperthyroidism and hypothyroidism.
• Metabolomics & Biomarker Discovery: Facilitates high-precision profiling of thyroid hormone pathways in large-scale studies investigating endocrine-disrupting chemicals, nutritional impacts, or disease states.
• Quality Control & Reference Material: Serves as a certified reference material (CRM) for calibrating analytical instruments and verifying the accuracy of in-house testing protocols in GLP/GMP environments.

Basic Information

Product Name	3,3',5'-Triiodothyronine-(Diiodophenyl-13C6) Hydrochloride
CAS No.	1217676-14-6
Molecular Formula	C15H1113C6I3NO4 • HCl
Molecular Weight	~ 790.81 g/mol (for unlabeled T3 HCl: 672.96 g/mol)
Synonyms	13C6-Labeled T3 Hydrochloride; [13C6]-T3 HCl; 3,3',5'-Triiodo-L-thyronine-(Diiodophenyl-13C6) Hydrochloride; Isotopically Labeled Liothyronine Hydrochloride; (2S)-2-Amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-13C6-phenyl]propanoic Acid Hydrochloride; Stable Isotope-Labeled Thyroid Hormone Standard; 13C6-L-T3 HCl; Mass Spectrometry Internal Standard for T3
EINECS	Contact for details

Quality Control

Our 3,3',5'-Triiodothyronine-(Diiodophenyl-13C6) Hydrochloride is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (≥99 atom % 13C), chemical purity (by HPLC, typically ≥98%), and confirming identity by spectroscopic methods. We adhere to industry best practices for reference material production, ensuring traceability and consistency for your critical research and development needs.

Storage

Preserve in a tightly closed container, protected from light. This product is strictly light-sensitive and hygroscopic (moisture-sensitive). For long-term stability, store at -20°C or below under desiccant. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. Store in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to expected mass
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Chemical Purity (by NMR)	Conforms
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.