Description

3-Fluoro-5-Pyrrolidinophenylboronic Acid is a high-value boronic acid derivative featuring a pyrrolidine substituent, making it a versatile and critical building block in modern synthetic chemistry. Its primary value lies in its role as a key coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, especially those targeting central nervous system (CNS) disorders.
• Suzuki-Miyaura Cross-Coupling: Serves as a key boronic acid reagent for palladium-catalyzed C-C bond formation to create complex biaryl and heterobiaryl scaffolds.
• Agrochemical Research: Used in the discovery and synthesis of new herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science: Employed in the development of organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology & Proteomics: Acts as a molecular probe or linker in the study of biological processes and protein interactions.
• Ligand Synthesis: Useful for creating novel ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	3-Fluoro-5-Pyrrolidinophenylboronic Acid
CAS No.	1217500-96-3
Molecular Formula	C10H13BFNO2
Molecular Weight	209.03 g/mol
Synonyms	(3-Fluoro-5-(pyrrolidin-1-yl)phenyl)boronic acid; 3-Fluoro-5-(1-pyrrolidinyl)benzeneboronic acid; 3-Fluoro-5-pyrrolidin-1-ylbenzeneboronic acid; 5-Pyrrolidin-1-yl-3-fluorobenzeneboronic acid; Boronic acid, B-[3-fluoro-5-(1-pyrrolidinyl)phenyl]-; 1217500-96-3; 3-Fluoro-5-pyrrolidinophenylboronic acid pinacol ester (common derivative)
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-Pyrrolidinophenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0% (Typical: ≥98.5%)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.