Description

2-Chloro-4-(Trifluoromethyl)Pyridine-5-Boronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its core value proposition lies in enabling the precise construction of complex molecules through reliable cross-coupling reactions, such as the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require a reliable, high-purity intermediate for developing new active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used to construct novel pyridine-based herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands and organometallic catalysts used in asymmetric synthesis and other advanced catalytic processes.
• Material Science Research: Employed in the development of organic electronic materials, such as those used in OLEDs and organic photovoltaics, due to its electron-withdrawing trifluoromethyl and chloro substituents.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Product Name	2-Chloro-4-(Trifluoromethyl)Pyridine-5-Boronic Acid
CAS No.	1217500-87-2
Molecular Formula	C7H4BClF3NO2
Molecular Weight	239.37 g/mol
Synonyms	5-Borono-2-chloro-4-(trifluoromethyl)pyridine; (2-Chloro-4-(trifluoromethyl)pyridin-5-yl)boronic acid; 2-Chloro-4-trifluoromethyl-5-pyridineboronic acid; 2-Chloro-4-(trifluoromethyl)-5-pyridinylboronic Acid; 2-Chloro-4-(trifluoromethyl)pyridine-5-boronic Acid Pinacol Ester (common derivative); 2-Chloro-4-(trifluoromethyl)-5-pyridylboronic acid
EINECS	Contact for details

Quality Control

Our production of 2-Chloro-4-(Trifluoromethyl)Pyridine-5-Boronic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for your critical synthesis steps. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and during weighing to prevent decomposition and maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.