Description

Methyl 2-Borono-4-(Trifluoromethoxy)Benzoate is a high-value organoboron building block, specifically a boronic ester derivative, essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for synthesizing novel active ingredients and functional molecules. The trifluoromethoxy substituent imparts unique electronic and metabolic properties, making it a sought-after intermediate for creating compounds with enhanced biological activity and stability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring the trifluoromethoxy pharmacophore for improved potency and pharmacokinetics.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the boronic ester group facilitates the introduction of complex aromatic systems.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, via cross-coupling to construct conjugated molecular architectures.
• Chemical Biology & Probe Development: Serves as a versatile handle for bioconjugation and the creation of molecular probes for imaging and diagnostic applications.
• Process Chemistry & Scale-up: A reliable reagent for the kilogram-scale production of fine chemicals under GMP or non-GMP conditions, depending on grade.
• Academic & Contract Research: Fundamental reagent for methodological development in cross-coupling catalysis and new synthetic route exploration in university and CRO laboratories.

Basic Information

Product Name	Methyl 2-Borono-4-(Trifluoromethoxy)Benzoate
CAS No.	1217500-75-8
Molecular Formula	C9H8BF3O5
Molecular Weight	264.0 g/mol
Synonyms	Methyl 2-Borono-4-(trifluoromethoxy)benzoate; 2-Borono-4-(trifluoromethoxy)benzoic Acid Methyl Ester; Methyl 4-(Trifluoromethoxy)-2-boronobenzoate; 2-(Methoxycarbonyl)-5-(trifluoromethoxy)phenylboronic Acid; [2-(Methoxycarbonyl)-5-(trifluoromethoxy)phenyl]boronic Acid; Boronic acid, B-[2-(methoxycarbonyl)-5-(trifluoromethoxy)phenyl]-; CAS 1217500-75-8
EINECS	Contact for details

Quality Control

Our Methyl 2-Borono-4-(Trifluoromethoxy)Benzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets stringent specifications for research and process use. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment. We can support development with custom purity grades, from standard research grade to high-purity standards suitable for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Standard Grade), ≥98% (High Purity Grade)
Assay (Boronate Content)	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.