Description

5-Hydroxy-2-(Trifluoromethoxy)Phenylboronic Acid is a specialized organoboron compound that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a boronic acid group for Suzuki-Miyaura cross-coupling reactions with a phenolic hydroxyl group for further derivatization. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who are developing novel active ingredients, particularly in the creation of complex molecules containing trifluoromethoxy and phenolic motifs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting the central nervous system, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides that require the trifluoromethoxy group for enhanced biological activity and stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of novel polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a tool compound or linker in the development of chemical probes, inhibitors, and bioconjugation strategies.
• Suzuki-Miyaura Cross-Coupling: Primarily utilized as a versatile boronic acid coupling partner to form biaryl and heterobiaryl carbon-carbon bonds under palladium catalysis.
• Complex Molecule Construction: Facilitates the modular synthesis of complex, polyfunctional molecules in medicinal chemistry and total synthesis projects.

Basic Information

Product Name	5-Hydroxy-2-(Trifluoromethoxy)Phenylboronic Acid
CAS No.	1217500-69-0
Molecular Formula	C7H6BF3O4
Molecular Weight	233.93 g/mol
Synonyms	[2-(Trifluoromethoxy)-5-hydroxyphenyl]boronic acid; (5-Hydroxy-2-(trifluoromethoxy)phenyl)boronic acid; 2-Trifluoromethoxy-5-hydroxybenzeneboronic acid; 5-Hydroxy-2-trifluoromethoxybenzeneboronic acid; Boronic acid, B-[2-(trifluoromethoxy)-5-hydroxyphenyl]-; 1217500-69-0
EINECS	Contact for details

Quality Control

Our 5-Hydroxy-2-(Trifluoromethoxy)Phenylboronic Acid is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with the standards required for cGMP and ISO-guided manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.