Description

L-Asparagine-15N2,D8 is a stable isotope-labeled analog of the amino acid L-Asparagine, specifically enriched with nitrogen-15 and deuterium. This compound is essential for advanced research applications requiring precise metabolic tracing and quantification, offering unparalleled accuracy in mass spectrometry and NMR studies. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for drug metabolism studies, proteomics, and biomarker discovery.

Application

• Internal Standard for Mass Spectrometry (MS): Used as a quantitative reference standard in LC-MS and GC-MS analyses for accurate measurement of endogenous L-Asparagine levels in complex biological matrices.
• Metabolic Pathway Tracing: Enables detailed investigation of nitrogen metabolism, amino acid synthesis, and protein turnover in cell culture, plant, and animal studies.
• Nuclear Magnetic Resonance (NMR) Spectroscopy: Serves as a probe for structural and dynamic studies of proteins and enzymes due to its distinct isotopic signature, eliminating background signal interference.
• Pharmaceutical Research & Development: Critical in pharmacokinetic (PK) and pharmacodynamic (PD) studies to track the absorption, distribution, metabolism, and excretion (ADME) of new drug candidates.
• Clinical Diagnostics: Potential use in developing advanced assays for metabolic disorders related to asparagine synthetase deficiency or certain types of leukemia.
• Nutritional Science Research: Employed in studies examining amino acid utilization, dietary protein metabolism, and sports nutrition.

Basic Information

Product Name	L-Asparagine-15N2,D8
CAS No.	1217473-37-4
Molecular Formula	C4H3D815N2O3
Molecular Weight	~137.15 g/mol
Synonyms	(2S)-2-Amino-3-carbamoylpropanoic-15N2,D8; L-Asparagine (amide-15N, 2,3,3,3-D4, 4,4,4-D4); L-2-Aminosuccinamic-15N2,D8 Acid; (S)-2-Aminosuccinamic-15N2,D8 Acid; L-α-Aminosuccinamic-15N2,D8 Acid; Isotopically Labeled L-Asparagine; [15N2,D8]-L-Asparagine; L-Asparagine-15N2,D8
EINECS	Contact for details

Quality Control

Our L-Asparagine-15N2,D8 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for critical research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (Atom % 15N and D), chemical purity by HPLC, chiral purity, and residual solvent content. We adhere to cGMP principles where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and analytical reference standard production.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure and isotopic pattern
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % 15N)	≥ 98%
Isotopic Enrichment (Atom % D)	≥ 98%
Chiral Purity (HPLC)	≥ 99.0% (L-Isomer)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.