Description

L-Asparagine-13C4,15N2,D8 CAS NO 1217464-18-0 is a highly specialized, multi-labeled stable isotope derivative of the amino acid L-Asparagine, incorporating carbon-13, nitrogen-15, and deuterium atoms at specific positions. This compound is critical for advanced quantitative mass spectrometry and metabolic flux analysis, providing unparalleled precision in tracing biochemical pathways. It is an essential research tool for scientists in pharmaceutical development, clinical diagnostics, and plant biochemistry who require definitive internal standards for accurate quantification.

Application

• Quantitative Proteomics & Metabolomics: Serves as an indispensable internal standard for the absolute quantification of L-Asparagine and related metabolites in complex biological samples using LC-MS/MS and GC-MS.
• Metabolic Pathway Tracing (Fluxomics): Used in 13C/15N metabolic flux analysis to map and quantify the flow of nutrients through central metabolic networks in cells, tissues, or whole organisms.
• Drug Metabolism & Pharmacokinetics (DMPK): Enables precise tracking of drug candidates and their metabolites that incorporate or interact with asparagine pathways, enhancing ADME studies.
• Clinical Research & Diagnostics: Facilitates the development of highly accurate diagnostic assays for inborn errors of metabolism, such as asparagine synthetase deficiency, and cancer research.
• Nutritional Science: Employed in studies investigating amino acid utilization, protein synthesis, and nitrogen balance in nutritional and physiological research.
• Plant & Agricultural Science: Used to study nitrogen assimilation, amino acid transport, and stress response mechanisms in plants.

Basic Information

Product Name	L-Asparagine-13C4,15N2,D8
CAS No.	1217464-18-0
Molecular Formula	¹³C₄H₅D₈¹⁵N₂O₃
Molecular Weight	~139.13 g/mol (labeled)
Synonyms	(2S)-2-Amino-3-carbamoylpropanoic-13C4,15N2,3,3,4,4,5,5,5,5-d8 acid; L-Asparagine-13C4,15N2,3,3,4,4,5,5,5,5-d8; L-Asn-13C4,15N2,D8; (S)-2-Amino-3-carbamoylpropanoic-13C4,15N2,D8 acid; Stable Isotope Labeled L-Asparagine; L-Asparagine (13C4, 15N2, D8); L-Asparagine-13C4,15N2,3,3,4,4,5,5,5,5-octadeuterio
EINECS	Contact for details

Quality Control

Every batch of L-Asparagine-13C4,15N2,D8 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, with comprehensive characterization by NMR (1H, 13C), Mass Spectrometry, and HPLC. Certificates of Analysis (COA) are provided with each shipment, detailing the isotopic enrichment, chemical purity, and chiral purity to meet the exacting standards of analytical and research laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a cool, dry place. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Chemical Purity)
Isotopic Enrichment	≥ 99 atom % 13C; ≥ 98 atom % 15N; ≥ 98 atom % D (by MS)
Optical Rotation	[α]20/D: +31.0° to +35.0° (c=1 in H2O)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.