Description

L-Theanine-D5 is a stable isotope-labeled analog of the naturally occurring amino acid L-Theanine, where five hydrogen atoms are replaced by deuterium. This compound is an essential analytical standard used for precise quantification and metabolic pathway tracing in research and quality control. It is primarily required by analytical laboratories, pharmaceutical R&D departments, and nutraceutical manufacturers engaged in advanced mass spectrometry and NMR studies.

Application

• Internal Standard for Quantitative Analysis: Used as a deuterated internal standard in LC-MS/MS and GC-MS methods for the accurate measurement of L-Theanine levels in dietary supplements, food products, and biological matrices.
• Metabolic and Pharmacokinetic Studies: Enables precise tracking of L-Theanine absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Pharmaceutical Impurity Profiling: Assists in the identification and quantification of process-related impurities or degradation products in pharmaceutical formulations containing L-Theanine.
• Nutraceutical Quality Assurance: Critical for verifying label claims and ensuring batch-to-batch consistency in high-purity L-Theanine ingredient manufacturing.
• Biochemical Research: Facilitates studies on the mechanism of action, neuropharmacology, and biochemical pathways influenced by L-Theanine.
• Certified Reference Material (CRM) Production: Serves as a primary material for the development of certified reference standards for regulatory compliance and method validation.

Basic Information

Product Name	L-Theanine-D5
CAS No.	1217451-85-8
Molecular Formula	C7H9D5N2O3
Molecular Weight	179.20 g/mol (approx.)
Synonyms	L-Glutamic acid γ-(ethyl-D5)-amide; N5-Ethyl-D5-L-glutamine; (2S)-2-Amino-4-[[(2,2,2,2',2')-pentadeuterioethyl]carbamoyl]butanoic acid; γ-Glutamylethyl-D5-amide; Suntheanine-D5; Deuterated L-Theanine; L-Theanine (ethyl-D5)
EINECS	Contact for details

Quality Control

Our L-Theanine-D5 is manufactured under strict quality control protocols to ensure high isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D%), chemical purity (by HPLC), and confirming structural identity. We support compliance with GMP guidelines for laboratory reagents and can provide materials tailored to specific pharmacopeial or internal standard requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D%)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.