Description

4-(Methylamino)-1-(3-Pyridyl)-1-Butanol-1,2',3',4',5',6'-13C6 is a stable isotope-labeled analog of a key nicotine metabolite, specifically enriched with carbon-13 at six positions on the pyridine ring. This compound is essential for quantitative mass spectrometry, providing an internal standard for unparalleled accuracy in pharmacokinetic and metabolic studies. It is primarily required by analytical laboratories, CROs, and pharmaceutical researchers focused on tobacco-related research, drug metabolism, and forensic toxicology.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of nicotine and its metabolites (like cotinine) in biological matrices such as plasma, urine, and saliva.
• Pharmacokinetic (PK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion in clinical and preclinical research.
• Metabolite Profiling & Biomarker Discovery: Used in research to identify and quantify novel metabolic pathways and biomarkers associated with nicotine exposure.
• Forensic & Clinical Toxicology: Supports accurate testing for nicotine consumption in workplace testing, anti-doping controls, and post-mortem analyses.
• Method Development & Validation: Serves as a reference material for developing and validating robust, GLP-compliant analytical methods.
• Environmental & Occupational Exposure Studies: Aids in monitoring nicotine uptake in studies related to second-hand smoke or occupational hazards.

Basic Information

Product Name	4-(Methylamino)-1-(3-Pyridyl)-1-Butanol-1,2',3',4',5',6'-13C6
CAS No.	1216991-24-0
Molecular Formula	C10H16N2O13C6
Molecular Weight	Contact for details
Synonyms	4-(Methylamino)-1-(pyridin-3-yl)butan-1-ol-1,2',3',4',5',6'-13C6; 3-Hydroxycotinine-1,2',3',4',5',6'-13C6; 3'-Hydroxycotinine-13C6; trans-3'-Hydroxycotinine-13C6; 4-(Methylamino)-1-(3-pyridinyl)-1-butanol-13C6; Nicotine Metabolite 13C6; 3HC-13C6; Labeled Internal Standard for Nicotine Metabolism
EINECS	Contact for details

Quality Control

Every batch of our 4-(Methylamino)-1-(3-Pyridyl)-1-Butanol-1,2',3',4',5',6'-13C6 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity as verified by advanced techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and solvent content is provided with each shipment to ensure traceability and support your regulatory compliance (GLP/GMP).

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C (at labeled positions)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.