Description

Nicotinic Acid-13C6,D4 is a high-purity, multi-isotope labeled internal standard essential for precise quantitative analysis. This compound is critical for ensuring accuracy and reliability in mass spectrometry-based methods, where unlabeled analogs can lead to significant analytical error. It is primarily required by analytical laboratories and research institutions in the pharmaceutical, clinical diagnostics, and metabolomics sectors for method development and validation.

Application

• Quantitative Mass Spectrometry: Serves as a stable-isotope labeled internal standard for the accurate LC-MS/MS quantification of nicotinic acid (Vitamin B3) and its metabolites in complex biological matrices.
• Pharmacokinetic & Bioavailability Studies: Enables precise tracking and measurement of drug absorption, distribution, metabolism, and excretion (ADME) for pharmaceutical development.
• Clinical Diagnostics: Used in assays to determine Vitamin B3 status, diagnose deficiencies (e.g., pellagra), and monitor nutritional interventions.
• Metabolomics Research: Facilitates the accurate profiling of tryptophan-nicotinate metabolic pathways in disease state investigations.
• Method Development & Validation: Provides a reference for developing and validating robust, GLP-compliant analytical methods in regulated environments.
• Quality Control in Nutraceuticals: Assists in the assay of Vitamin B3 content in fortified foods and dietary supplements.

Basic Information

Product Name	Nicotinic Acid-13C6,D4
CAS No.	1216798-74-1
Molecular Formula	13C6C5D4NO2
Molecular Weight	~131.10 g/mol
Synonyms	Pyridine-3-carboxylic acid-13C6,D4; Vitamin B3-13C6,D4; Niacin-13C6,D4; 3-Carboxypyridine-13C6,D4; Nicotinate-13C6,D4; [13C6,D4]-Nicotinic Acid; [Ring-13C6, 2,4,5,6-D4]-Nicotinic Acid; Isotopically Labeled Nicotinic Acid
EINECS	Contact for details

Quality Control

Every batch of Nicotinic Acid-13C6,D4 is manufactured and analyzed under strict quality systems. We provide comprehensive Certificates of Analysis (COA) detailing isotopic purity (chemical and isotopic), chemical purity, and solvent content. Our quality commitment aligns with the standards expected for high-value reference materials in pharmaceutical and analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive); ensure containers are sealed immediately after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to expected mass
Purity (HPLC)	≥ 98% (chemical purity)
Isotopic Purity	≥ 99 atom % 13C; ≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.