Description

4,5-Difluoro-2-Hydroxy-Benzoic Acid Methyl Ester is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound matters as a key intermediate in the development of active pharmaceutical ingredients (APIs), agrochemicals, and functional materials, where its difluoro-hydroxy-benzoate structure enables precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other biologically active molecules.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and pesticides, leveraging the fluorine atoms for enhanced bioactivity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Chemical Research & Development: Employed as a versatile synthon in academic and industrial labs for exploring new fluorination reactions and constructing complex aromatic systems.
• Specialty Polymer Modification: Can be incorporated into polymer backbones to impart specific properties like altered solubility, thermal stability, or optical characteristics.

Basic Information

Product Name	4,5-Difluoro-2-Hydroxy-Benzoic Acid Methyl Ester
CAS No.	1214375-32-2
Molecular Formula	C9H6F2O3
Molecular Weight	200.14 g/mol
Synonyms	Methyl 4,5-difluoro-2-hydroxybenzoate; 2-Hydroxy-4,5-difluorobenzoic acid methyl ester; 4,5-Difluorosalicylate methyl ester; Benzoic acid, 4,5-difluoro-2-hydroxy-, methyl ester; Methyl 4,5-difluoro-2-hydroxybenzoate; 1214375-32-2; 4,5-Difluoro-2-hydroxybenzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our 4,5-Difluoro-2-Hydroxy-Benzoic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.