Description

Methyl 3-Chloro-2,4,5-Trifluorobenzoate is a high-purity fluorinated aromatic ester building block essential for advanced organic synthesis. This compound is valued for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of fluorine atoms is critical for modulating biological activity and metabolic stability. It is primarily utilized by research and development chemists and process scale-up teams in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly those containing trifluoromethyl or difluoromethyl groups.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides where fluorination enhances efficacy and environmental persistence.
• Liquid Crystal Materials: Serves as a building block for fluorinated components in liquid crystal displays (LCDs) due to its stable aromatic core and fluorine substituents.
• Organic Electronic Materials: Employed in the research and development of organic semiconductors and electron-transport materials.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Chemical Research & Development: A versatile reagent for exploring new fluorination methodologies and constructing diverse chemical libraries for screening.

Basic Information

Product Name	Methyl 3-Chloro-2,4,5-Trifluorobenzoate
CAS No.	1214375-02-6
Molecular Formula	C8H4ClF3O2
Molecular Weight	232.56 g/mol
Synonyms	Methyl 3-chloro-2,4,5-trifluorobenzoate; Benzoic acid, 3-chloro-2,4,5-trifluoro-, methyl ester; 3-Chloro-2,4,5-trifluorobenzoic acid methyl ester; Methyl 3-chloro-2,4,5-trifluorobenzenecarboxylate
EINECS	Contact for details

Quality Control

Our Methyl 3-Chloro-2,4,5-Trifluorobenzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for each lot to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.