Description

(R)-2-Amino-5-(1-Amino-2,2,2-Trifluoro-Ethyl)-4-Fluoro-Benzoic Acid is a high-value, chiral fluorinated benzoic acid derivative, serving as a critical advanced pharmaceutical intermediate. Its molecular structure, featuring a trifluoroethyl-amino side chain and fluorine substitution, makes it essential for synthesizing novel, potent active pharmaceutical ingredients (APIs). This compound is primarily targeted at research and development organizations and pharmaceutical manufacturers engaged in creating next-generation therapeutics, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel, fluorinated active pharmaceutical ingredients (APIs).
• Drug Discovery & Development: Used in medicinal chemistry research for structure-activity relationship (SAR) studies and lead optimization.
• Protease Inhibitor Synthesis: Potential precursor in the development of enzyme inhibitors due to its unique amino acid-like structure.
• Agrochemical Research: Intermediate for developing new fluorinated pesticides and herbicides with enhanced activity and selectivity.
• Material Science: Can be utilized in the synthesis of specialty polymers and advanced organic materials.
• Contract Manufacturing (CMO/CDMO): Supplied to contract manufacturing organizations for custom synthesis and scale-up projects.

Basic Information

Item	Details
Product Name	(R)-2-Amino-5-(1-Amino-2,2,2-Trifluoro-Ethyl)-4-Fluoro-Benzoic Acid
CAS No.	1213947-44-4
Molecular Formula	C9H8F4N2O2
Molecular Weight	252.17 g/mol
Synonyms	(R)-2-Amino-5-(1-amino-2,2,2-trifluoroethyl)-4-fluorobenzoic acid; (R)-4-Fluoro-2-amino-5-(1-amino-2,2,2-trifluoroethyl)benzoic acid; 1213947-44-4; Benzoic acid, 2-amino-5-(1-amino-2,2,2-trifluoroethyl)-4-fluoro-, (R)-; (R)-AATFEB; (R)-enantiomer of AATFEB
EINECS	Contact for details

Quality Control

Our (R)-2-Amino-5-(1-Amino-2,2,2-Trifluoro-Ethyl)-4-Fluoro-Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.