Description

(1S)-1-[4-(Difluoromethyl)Phenyl]Ethylamine is a high-purity chiral amine building block of significant interest in advanced organic synthesis. Its value lies in its unique structure, featuring a difluoromethyl group and a stereogenic center, which makes it a critical intermediate for developing novel pharmaceuticals and agrochemicals. This compound is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of active pharmaceutical ingredients (APIs), particularly in candidates targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the difluoromethyl moiety can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to achieve high enantioselectivity.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials that require fluorinated aromatic components for specific electronic or surface properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	(1S)-1-[4-(Difluoromethyl)Phenyl]Ethylamine
CAS No.	1213446-58-2
Molecular Formula	C9H11F2N
Molecular Weight	171.19 g/mol
Synonyms	(S)-1-(4-(Difluoromethyl)phenyl)ethan-1-amine; (S)-α-Methyl-4-(difluoromethyl)benzylamine; (1S)-1-[4-(Difluoromethyl)phenyl]ethanamine; (S)-1-[4-(Difluoromethyl)phenyl]ethylamine; Benzenemethanamine, α-methyl-4-(difluoromethyl)-, (αS)-; (S)-(-)-1-[4-(Difluoromethyl)phenyl]ethylamine
EINECS	Contact for details

Quality Control

Our (1S)-1-[4-(Difluoromethyl)Phenyl]Ethylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and purity assessment, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.