Description

4-Amino-5-Bromo-2-(Trifluoromethyl)Benzoic Acid is a high-value, multi-functional aromatic building block characterized by its trifluoromethyl, bromo, and amino substituents. This compound is essential for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its unique halogenated and fluorinated structure imparts critical biological activity and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and advanced polymers with tailored electronic properties.
• Chemical Biology Probes: Utilized to create fluorescent tags or molecular probes for studying biological processes and target engagement.
• Custom Synthesis and Contract Manufacturing: A critical building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	4-Amino-5-Bromo-2-(Trifluoromethyl)Benzoic Acid
CAS No.	1208076-77-0
Molecular Formula	C8H5BrF3NO2
Molecular Weight	284.03 g/mol
Synonyms	5-Bromo-4-amino-2-(trifluoromethyl)benzoic acid; 2-(Trifluoromethyl)-4-amino-5-bromobenzoic acid; 4-Amino-5-bromo-α,α,α-trifluoro-o-toluic acid; Benzoic acid, 4-amino-5-bromo-2-(trifluoromethyl)-; 1208076-77-0; 4-Amino-5-bromo-2-trifluoromethylbenzoic acid
EINECS	Contact for details

Quality Control

Every batch of 4-Amino-5-Bromo-2-(Trifluoromethyl)Benzoic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing all specifications are available upon request, providing full traceability and compliance assurance for your regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.