Description

3,4-Bis(Trifluoromethyl)Phenylboronic Acid is a high-value organoboron building block characterized by its electron-deficient aromatic ring system. This compound is critical for enabling the synthesis of complex molecules through versatile cross-coupling reactions, such as the Suzuki-Miyaura reaction. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders and oncology, where the trifluoromethyl groups enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides, leveraging the lipophilicity and stability imparted by the bis(trifluoromethyl) moiety.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers, liquid crystals, and organic electronic materials (OLEDs, OFETs) due to its electron-withdrawing properties.
• Chemical Research & Development: Employed in academic and industrial R&D for method development in palladium-catalyzed cross-coupling reactions and for creating complex molecular libraries.
• Ligand and Catalyst Design: Utilized to synthesize novel bidentate or monodentate ligands for transition metal catalysis.

Basic Information

Product Name	3,4-Bis(Trifluoromethyl)Phenylboronic Acid
CAS No.	1204745-88-9
Molecular Formula	C8H5BF6O2
Molecular Weight	257.93 g/mol
Synonyms	[3,4-Bis(trifluoromethyl)phenyl]boronic acid; 3,4-Bis(trifluoromethyl)benzeneboronic acid; (3,4-Bis(trifluoromethyl)phenyl)boronic acid; Boronic acid, B-[3,4-bis(trifluoromethyl)phenyl]-; 3,4-Di(trifluoromethyl)phenylboronic acid; 3,4-Bis(trifluoromethyl)phenyl-B(OH)2; 1204745-88-9
EINECS	Contact for details

Quality Control

Every batch of 3,4-Bis(Trifluoromethyl)Phenylboronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for sensitive cross-coupling applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (NMR)	Conforms
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.