Description

Methyl 5-Fluoro-2-Iodobenzoate is a high-purity, multi-functional halogenated benzoate ester serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine and iodine atoms on the aromatic ring, which allows for selective cross-coupling reactions and further functionalization. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated and iodinated aromatic systems for enhanced bioactivity and metabolic stability.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the fluorine atom can improve lipophilicity and target binding.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and liquid crystals with unique electronic or optical properties.
• Cross-Coupling Reactions: The iodine moiety makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Sonogashira couplings to construct complex biaryl structures.
• Chemical Biology & Diagnostics: Utilized as a labeling reagent or a scaffold for developing molecular probes and imaging agents due to the potential for radioiodination.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for constructing diverse heterocyclic compounds and complex natural product analogs.

Basic Information

Item	Details
Product Name	Methyl 5-Fluoro-2-Iodobenzoate
CAS No.	1202897-48-0
Molecular Formula	C8H6FIO2
Molecular Weight	280.04 g/mol
Synonyms	Benzoic acid, 5-fluoro-2-iodo-, methyl ester; Methyl 5-fluoro-2-iodobenzoate; 5-Fluoro-2-iodobenzoic acid methyl ester; 2-Iodo-5-fluorobenzoic acid methyl ester; Methyl 2-iodo-5-fluorobenzoate
EINECS	Contact for details

Quality Control

Our Methyl 5-Fluoro-2-Iodobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and production. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling should be minimized under direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.