Description

D-Tryptophan-D5 is a stable isotope-labeled analog of the essential amino acid L-tryptophan, where five hydrogen atoms are replaced by deuterium. This high-purity compound is critical for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy in analytical measurements. It is an indispensable tool for researchers and quality control laboratories in the pharmaceutical, clinical diagnostics, and nutritional science industries, where precise quantification of tryptophan and its metabolites is required.

Application

• Mass Spectrometry Internal Standard: Primary use as a deuterated internal standard for the accurate quantification of L-tryptophan and related indole compounds in LC-MS/MS and GC-MS analyses.
• Pharmaceutical Research & Metabolism Studies: Enables precise tracking and pharmacokinetic analysis of tryptophan pathways in drug development and metabolic research.
• Clinical Diagnostics: Used in assays to measure tryptophan and kynurenine pathway metabolites in biological fluids for research into neurological disorders, immune function, and cancer.
• Nutritional Science & Supplement Analysis: Facilitates the accurate determination of tryptophan content in protein hydrolysates, dietary supplements, and fortified foods.
• Isotope Dilution Analysis (IDA): Serves as the labeled spike in IDA protocols, the gold-standard method for achieving high metrological accuracy in complex matrices.
• Biochemical Research: Aids in mechanistic studies of enzyme kinetics and protein biosynthesis where isotopic tracing is necessary.

Basic Information

Product Name	D-Tryptophan-D5
CAS No.	1202359-57-6
Molecular Formula	C11H7D5N2O2
Molecular Weight	209.25 g/mol
Synonyms	(2S)-2-Amino-3-(5-deuterio-1H-indol-3-yl)(2H3)propanoic acid; (S)-2-Amino-3-(5-deuterio-1H-indol-3-yl)-3,3,3-trideuteriopropanoic acid; D-Tryptophan-2,3,3,3-d4-(indole-5-d); Deuterated Tryptophan; Tryptophan-d5; [2,3,3,3-d4,5-d]-L-Tryptophan; L-Tryptophan-2,3,3,3-d4-(indole-5-d)
EINECS	Contact for details

Quality Control

Our D-Tryptophan-D5 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % D), chemical purity (by HPLC), and chiral purity. We adhere to relevant industry standards for high-purity reference materials to guarantee reliable and reproducible performance in your sensitive analytical methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.