Description

Pradefovir Mesylate is a key pharmaceutical intermediate and active metabolite of the prodrug pradefovir, a potent antiviral agent. This compound is critical for research and development targeting chronic hepatitis B virus (HBV) infections. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in antiviral drug discovery and advanced therapeutic development. Our supply ensures high purity and consistency, supporting critical pre-clinical and clinical-stage work.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a crucial building block in the synthesis of pradefovir and related nucleotide analog prodrugs.
• Antiviral Research & Development: Used as a reference standard and biological tool in virology studies to understand the mechanism of action against hepatitis B virus.
• Pre-clinical and Clinical Studies: Essential for pharmacokinetic, pharmacodynamic, and toxicology evaluations during drug development phases.
• Process Chemistry & Scale-Up: Employed in the development and optimization of robust, scalable synthetic routes for manufacturing.
• Analytical Method Development: Acts as a high-purity standard for establishing and validating HPLC, LC-MS, and other analytical protocols.
• Formulation Development: Used in studies to develop stable and bioavailable dosage forms for potential therapeutic use.

Basic Information

Product Name	Pradefovir Mesylate
CAS No.	1202000-62-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	9-[(R)-2-[[(S)-[[(S)-(1-Hydroxy-2-methyl-1-oxopropan-2-yl)amino]phenoxyphosphinyl]methoxy]propyl]adenine methanesulfonate; PMPA Prodrug Mesylate; GS-7340 Mesylate; (R)-PMPA Prodrug Mesylate; Pradefovir Methanesulfonate; 9-(2-Phosphonylmethoxypropyl)adenine Prodrug Mesylate
EINECS	Contact for details

Quality Control

Our Pradefovir Mesylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) with detailed chromatographic data (HPLC) are provided for every shipment. We support compliance with cGMP and ICH guidelines for advanced pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH limits
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.