Description

3-Fluoro-4-Trifluoromethoxy-Benzoic Acid Ethyl Ester is a high-value fluorinated aromatic building block essential for advanced organic synthesis. This compound matters because its unique trifluoromethoxy and fluorine substituents impart significant lipophilicity and metabolic stability, making it a critical intermediate for developing novel active compounds. It is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries seeking to enhance the properties of their target molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorine motifs improve biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic cores used in electronic display technologies and organic light-emitting diodes.
• Advanced Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, enhancing their chemical resistance, thermal stability, and surface properties.
• Chemical Research & Development: A versatile reagent in academic and industrial labs for exploring new fluorination methodologies and creating complex molecular architectures.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of tailored compounds under cGMP or research-grade conditions.

Basic Information

Product Name	3-Fluoro-4-Trifluoromethoxy-Benzoic Acid Ethyl Ester
CAS No.	1197231-80-3
Molecular Formula	C10H8F4O3
Molecular Weight	252.16 g/mol
Synonyms	Ethyl 3-Fluoro-4-(trifluoromethoxy)benzoate; Benzoic acid, 3-fluoro-4-(trifluoromethoxy)-, ethyl ester; 3-Fluoro-4-trifluoromethoxybenzoic acid ethyl ester; Ethyl 3-fluoro-4-trifluoromethoxybenzoate; 4-(Trifluoromethoxy)-3-fluorobenzoic Acid Ethyl Ester; CAS 1197231-80-3
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-Trifluoromethoxy-Benzoic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. For advanced applications, we can supply material that meets research-grade or cGMP standards upon request, ensuring reliable integration into your sensitive synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (GC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.